Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Learn about tamoxifen and other hormone therapies for metastatic breast cancer. Hormone receptor-positive breast cancers need estrogen and/or progesterone (female hormones produced in the body) to grow. Tamoxifen attaches to the hormone receptor in the cancer cell, blocking estrogen from attaching to the receptor. This slows or stops the growth of the tumor by preventing the cancer cells from getting the hormones they need to grow. Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it. For some women with breast cancer, taking adjuvant tamoxifen (Nolvadex®) for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial. The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium (SABCS) and published in on December 5, 2012—are likely to change clinical practice, several researchers said. Nearly 7,000 women with early-stage, estrogen receptor-positive breast cancer were enrolled in the trial between 19. After taking tamoxifen for 5 years, participants were randomly assigned to continue taking tamoxifen for another 5 years or to stop taking it. From 5 to 9 years after the women began tamoxifen therapy, there was little difference in outcomes between the two treatment groups. This finding is consistent with those from other trials of adjuvant tamoxifen therapy, which showed that 5 years of tamoxifen can substantially reduce the risk of the cancer returning and of cancer death in the next few years, what one of the trial investigators, Richard Gray, MSc, of Oxford University, UK, called a "carryover effect." The improved outcomes with longer tamoxifen use emerged only after the 10-year mark, Gray explained during an SABCS press briefing. Among the women who took tamoxifen for 10 years, the risk of breast cancer returning between 10 and 14 years after starting tamoxifen was 25 percent lower than it was among women who took it for 5 years, and the risk of dying from breast cancer was nearly 30 percent lower. Tamoxifen injection Buy prednisone 1mg Jan 10, 2006. My mother is a 5 year breast cancer survivor. Her oncologist recently took her off Tamoxifen after her 5 year anniversary. She gradually weaned. Apr 27, 2017. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen-receptor-positive breast. Fifteen years after treatment, almost 6 fewer recurrences would be seen. Differences in both overall survival and deaths from breast cancer also favored the longer duration of tamoxifen treatment for up to 12 years after treatment. The benefits of 5 years of tamoxifen were seen in both premenopausal and postmenopausal women. Does anyone have any information on what to expect after 5 years of tamoxifen - I just finished 5 years of the medication this month. My cancer was caught early and all I had was radiation. I am 54 years old and looking for next steps after medication. Tamoxifen is some kind of an estrogen with ability to block the cancer's estrogen receptors. But after breast cancer, you can't take hormone replacement. I feel like after five years of a medication the doctors would have more to say. It seems like you would start to go thru menopause, if you haven't already. I did ask my doctor what's next and "he" said I would have to wait and see. It's amazing no data is out there for my age group so I will keep a journal so I can help some else. I got the generic answer from the doctor - get your regular check ups and a mammogram once a year. I have contacted a naturopathic doctor to discuss next steps. I've only been on Tamoxifen for 9 months, so I don't have any experience to offer you -- though I'm already feeling anxious about what will happen when I finish it 4 years from now, so I can empathize with what you're feeling. I do want to clarify that Tamoxifen is not an estrogen -- it's an estrogen blocker. Its purpose is to reduce the possibility that the estrogen your body produces will gain access to any cancer cells, and, in the process, often affects the way other parts of your body use estrogen, too, which is why it can cause menopause-like symptoms, such as hot flashes, vaginal dryness, irregular periods, etc. Hello I have not been on this site for a long time- it really helped on my cancer journey- the club no one wants to belong to!!!! But we're glad you felt able to pop back to see if you could connect with anyone who might be able to share their experiences of stopping Tamoxifen. I have recently stopped tamoxifen reducing over a couple of weeks 20mgto 10 mgthen ran out so just stopped - I have had really bad hot flashes shessince- I wonder how long this will go on?? I've had a search through the forum but unfortunately can't find any recent posts to link for you. It's great to hear that the forum really helped you during your journey and yes you're right, it's certainly the club that no one wants to belong to! I'm going to ask our team of nurses if they are able to respond with any information/links that might be helpful so hopefully you will hear from them in the next few days. Sending our best wishes Jenn Cancer Chat moderator Hi, I am so sorry to hear about the hot flushes you are having after stopping Tamoxifen. I have had 2 bouts of cancer within a year of each other. The first was 8 years ago and I had a lumpectomy, followed by Tamoxifen for a year. Tamoxifen after 5 years Tamoxifen Uses, Side Effects, and More -, Vs 5 years of adjuvant tamoxifen exclusion of 1/402 centres in. Can you order acyclovir onlineDoes amoxicillin contain sulfaViagra vision changes Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it. Tamoxifen for Breast Cancer Treatment - Side Effects.. Five Years of Tamoxifen Continues to Benefit Women 15.. Long-term effects of continuing adjuvant tamoxifen to 10 years versus.. The benefits from tamoxifen last long after you stop taking it. These findings have led to increased use of tamoxifen for more than 5 years, especially among. After taking tamoxifen for 5 years, participants were randomly assigned to continue taking tamoxifen for another 5 years or to stop taking it. From 5 to 9 years after the women began tamoxifen therapy, there was little difference in outcomes between the two treatment groups. Because the decrease in breast cancer mortality produced by 5 years of tamoxifen continues to be substantial for a decade after treatment ends ie, throughout the first 15 years after diagnosis, trials of 10 years versus 5 years of tamoxifen will need to be followed up for at least 15 years from diagnosis.