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    Memory reconsolidation impairment using the β-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post-traumatic stress disorder (PTSD). However, in order to better inform targeted treatment development, the effects of this compound on memory need to be better characterized via translational research. We examined the effects of systemic propranolol administration in mice undergoing a wide range of behavioral tests to determine more specifically which aspects of the memory consolidation and reconsolidation are impaired by propranolol. We found that propranolol (10 mg/kg) affected memory consolidation in non-aversive tasks (object recognition and object location) but not in moderately (Morris water maze (MWM) to highly (passive avoidance, conditioned taste aversion) aversive tasks. doi: 10.3389/fnbeh.2016.00049 © 2016 Villain, Benkahoul, Drougard, Lafragette, Muzotte, Pech, Bui, Brunet, Birmes and Roullet. Further, propranolol impaired memory reconsolidation in the most and in the least aversive tasks, but not in the moderately aversive task, suggesting its amnesic effect was not related to task aversion. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Moreover, in aquatic object recognition and location tasks in which animals were forced to behave (contrary to the classic versions of the tasks); propranolol did not impair memory reconsolidation. The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Taken together our results suggest that the memory impairment observed after propranolol administration may result from a modification of the emotional valence of the memory rather than a disruption of the contextual component of the memory trace. doi: 10.1016/j.psychres.20 Pub Med Abstract | Cross Ref Full Text | Google Scholar Villain H, Benkahoul A, Drougard A, Lafragette M, Muzotte E, Pech S, Bui E, Brunet A, Birmes P and Roullet P (2016) Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice. No use, distribution or reproduction is permitted which does not comply with these terms. Propranolol's effects on the consolidation and reconsolidation of. Propranolol Before Memory Recall May Ease PTSD Symptoms. PTSD Symptom Reduction by Propranolol Given After Trauma.
     
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